منابع مشابه
Adiponectin alleviate blood hypercoagulability via inhibiting endothelial cell apoptosis induced by oxidative stress in septic rats
Objective(s): The purpose of this study was to detect the protective effects of adiponectin on coagulation dysfunction and its mechanism in sepsis of rats.Materials and Methods: The experimental samples were composed of sham group, model group that was underwent cecal ligation and puncture (CLP) and three adiponectin treatment groups that treated by adiponectin with different dose (72 μg/kg, ...
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BACKGROUND CD39 is the dominant vascular nucleoside triphosphate diphosphohydrolase (NTPDase) that exerts major effects on platelet reactivity by the regulated hydrolysis of extracellular adenine nucleotides. The effects of NTPDases on endothelial cell (EC) activation and apoptosis remain unexplored. MATERIAL AND METHODS Recombinant replication-deficient adenoviruses were constructed with hum...
متن کاملEndothelial apoptosis.
We read with interest the excellent review by Stefanec (March 2000),1 which summarized the knowledge about endothelial apoptosis. Table 2 of his article represented the proand antiapoptotic stimuli for endothelial cells. Herein, we would like to add activating a topic receptor as a proapoptotic stimulus for its cells in the Table. Activation of peroxisome proliferator-activated receptor (PPAR)-...
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The process of angiogenesis plays an important role in many physiological and pathological conditions. Inhibition of endothelial cell (EC) apoptosis providing EC survival is thought to be an essential mechanism during angiogenesis. Many of the angiogenic growth factors inhibit EC apoptosis. In addition, the adhesion of ECs to the extracellular matrix or intercellular adhesion promotes EC surviv...
متن کاملAntiphospholipid reactivity against cardiolipin metabolites occurring during endothelial cell apoptosis
We have recently shown that cardiolipin (CL) and its metabolites move from mitochondria to other cellular membranes during death receptor-mediated apoptosis. In this study, we investigate the immunoreactivity to CL derivatives occurring during endothelial apoptosis in patients with antiphospholipid syndrome (APS) and systemic lupus erythematosus (SLE). We compared the serum immunoreactivity to ...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2012
ISSN: 0009-7330,1524-4571
DOI: 10.1161/circresaha.112.278713